CONNECT | GROW | TRANSFORM

Seed oils rich in linoleic acid (LA), such as soybean, corn, sunflower, safflower, and canola oil, provide the exact substrate (PUFAs) that enzymes like lipoxygenase (LOX) and myeloperoxidase (MPO) use to oxidise LDL particles.

What’s actually most prone to oxidation in LDL is the fatty acid tail of the cholesteryl ester in the “oil barrel” (and the PUFA in the phospholipid shell). Cholesterol itself — the rigid steroid ring — is remarkably stable. Pure cholesterol won’t just oxidise easily in the body.

When the metabolic environment is calm — low inflammation, low oxidative stress, good insulin sensitivity — LDL particles circulate, deliver nutrients, and return to the liver without incident. But in an inflamed environment, those same particles can get trapped, oxidised, and turned into plaque.